Circadian changes in mitoxantrone toxicity in mice: relationship with plasma pharmacokinetics.

@article{Lvi1994CircadianCI,
  title={Circadian changes in mitoxantrone toxicity in mice: relationship with plasma pharmacokinetics.},
  author={Francis A L{\'e}vi and Marco Tampellini and Greg Metzger and E Bizi and Guy Lemaigre and Michael J Hallek},
  journal={International journal of cancer},
  year={1994},
  volume={59 4},
  pages={543-7}
}
Circadian time-dependent differences in clinical toxicity of several anti-cancer agents were predicted from murine studies. Mitoxantrone is an anthracenedion (an anthracycline-related class of compounds) of increased clinical use, which may benefit from selective circadian timing. In 3 consecutive studies, a total of 428 male B6D2F1 mice aged from 8 to 10 weeks were synchronized by an alternation of 12 hr of light and 12 hr of darkness (LD 12:12). They received a single i.v. injection of… CONTINUE READING

Similar Papers

Loading similar papers…