Circadian and wake-dependent effects on the pupil light reflex in response to narrow-bandwidth light pulses.

@article{Mnch2012CircadianAW,
  title={Circadian and wake-dependent effects on the pupil light reflex in response to narrow-bandwidth light pulses.},
  author={M. M{\"u}nch and Lorette L{\'e}on and Sylvain Vincent Crippa and Aki K Kawasaki},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 8},
  pages={4546-55}
}
PURPOSE Nonvisual light-dependent functions in humans are conveyed mainly by intrinsically photosensitive retinal ganglion cells, which express melanopsin as photopigment. We aimed to identify the effects of circadian phase and sleepiness across 24 hours on various aspects of the pupil response to light stimulation. METHODS We tested 10 healthy adults hourly in two 12-hour sessions covering a 24-hour period. Pupil responses to narrow bandwidth red (635 ± 18 nm) and blue (463 ± 24 nm) light… CONTINUE READING