Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness.

@article{Zeitzer2003CircadianAH,
  title={Circadian and homeostatic regulation of hypocretin in a primate model: implications for the consolidation of wakefulness.},
  author={Jamie M Zeitzer and Christine L. Buckmaster and Karen J Parker and Craig M Hauck and David M. Lyons and Emmanuel Mignot},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 8},
  pages={3555-60}
}
In humans, consolidation of wakefulness into a single episode can be modeled as the interaction of two processes, a homeostatic "hour-glass" wake signal that declines throughout the daytime and a circadian wake-promoting signal that peaks in the evening. Hypocretins, novel hypothalamic neuropeptides that are dysfunctional in the sleep disorder narcolepsy, may be involved in the expression of the circadian wake-promoting signal. Hypocretins (orexins) are wake-promoting peptides, but their role… CONTINUE READING
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