Circadian and acamprosate modulation of elevated ethanol drinking in mPer2 clock gene mutant mice.

@article{Brager2011CircadianAA,
  title={Circadian and acamprosate modulation of elevated ethanol drinking in mPer2 clock gene mutant mice.},
  author={Allison J. Brager and Rebecca A Prosser and John David Glass},
  journal={Chronobiology international},
  year={2011},
  volume={28 8},
  pages={
          664-72
        }
}
The PER2 clock gene modulates ethanol consumption, such that mutant mice not expressing functional mPer2 have altered circadian behavior that promotes higher ethanol intake and preference. Experiments were undertaken to characterize circadian-related behavioral effects of mPer2 deletion on ethanol intake and to explore how acamprosate (used to reduce alcohol dependence) alters diurnal patterns of ethanol intake. Male mPer2 mutant and WT (wild-type) mice were entrained to a 12:12 h light-dark… CONTINUE READING

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Chronic ethanol disrupts circadian behavior and photic phase-resetting in the hamster

  • CL Ruby, AJ Brager, DePaulMA, RA Prosser, JD. Glass
  • Am. J. Physiol. 297:R729–R737
  • 2009
Highly Influential
4 Excerpts

Circadian genes are involved in alcohol related behaviors in Drosophila melanogaster

  • JB Pohl, N Sherazee, A Ghezzi, NS. Atkinson
  • Alcohol. Clin. Exp. Res. 34:p477A
  • 2010
1 Excerpt

ClockΔ19 mutants exhibit increased ethanol preference and consumption

  • AR Ozburn, EA Gordon, CA. McClung
  • Alcohol. Clin. Exp. Res
  • 2010
3 Excerpts

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