Circadian and Circannual Rhythms in Thyroid Hormones: Determining the TSH and Free T4 Reference Intervals Based Upon Time of Day, Age, and Sex.

@article{Ehrenkranz2015CircadianAC,
  title={Circadian and Circannual Rhythms in Thyroid Hormones: Determining the TSH and Free T4 Reference Intervals Based Upon Time of Day, Age, and Sex.},
  author={Joel R L Ehrenkranz and Phillip R Bach and Gregory L. Snow and Alison Schneider and Jo Lynn Lee and S J Ilstrup and Sterling T. Bennett and Salvatore Benvenga},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2015},
  volume={25 8},
  pages={954-61}
}
BACKGROUND Establishing the reference interval for thyrotropin (TSH) and free thyroxine (T4) is clinically important because a number of disease states have been linked to alterations in TSH and free T4 concentrations that are within the 95% confidence interval for normal thyroid hormone values. Age, sex, time of day, and ethnicity are known to affect circulating levels of TSH and free T4 but have not been used to establish reference intervals. The purpose of this study was to define the… CONTINUE READING

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