Circadian Rhythms: Influence of Light in Humans

@inproceedings{Lockley2009CircadianRI,
  title={Circadian Rhythms: Influence of Light in Humans},
  author={Steven W. Lockley},
  year={2009}
}
Many aspects of human physiology and behavior are dominated by 24 h rhythms that have a major impact on our health and well-being. The daily light-dark cycle plays the primary role in synchronizing these rhythms with the 24 h day. The properties of light that determine the efficacy of its circadian phase-resetting effects include the timing, intensity, duration, pattern, wavelength, and history of exposure. Major advances have been made in understanding how light is detected by the eye to reset… Expand
View via Publisher
blog.lsgc.com
56 Citations
Highly Influential Citations
4
Background Citations
21

56 Citations

Citation Type

Citation Type

Light and chronobiology: implications for health and disease
TLDR
Tailoring and optimizing indoor lighting conditions may be an approach to improve wellbeing, alertness, and cognitive performance and, in the long term, producing health benefits. Expand
Measuring circadian lighting through high dynamic range photography
TLDR
Tristimulus colour calibration procedures for high dynamic range photography are developed to measure circadian lighting and demonstrate that measurements from high dynamicrange photographs can correspond to the physical quantity of circadian luminance with reasonable precision and repeatability. Expand
Disruption of circadian rhythmicity – An exploratory study in Poland
Abstract A comparison of the ratio of morningness/eveningness among students in the years 2005 and again 2011 in Poland revealed an increase in the number of people preferring evening activity (from… Expand
SPECTRAL DAYLIGHTING SIMULATIONS : COMPUTING CIRCADIAN LIGHT
Recent studies have demonstrated that the spectral content of light at typical interior daylight levels affects human circadian rhythms. Lighting simulation tools are developed, used, and validated… Expand
A framework for predicting the non-visual effects of daylight – Part I: photobiology- based model
This paper investigates the formulation of a modelling framework for the non-visual effects of daylight, such as entrainment of the circadian system and maintenance of alertness. The body of… Expand
Night-time activity forecast by season and weather in a longitudinal design – natural light effects on three years’ rest-activity cycles in nursing home residents with dementia
TLDR
The need for sufficient zeitgeber (time cue) strength during winter time, especially when days are short and skies are cloudy, is crucial for elderly people living with dementia. Expand
Simulation-based evaluation of non-visual responses to daylight: Proof-of-concept study of healthcare re-design
The discovery of a novel non-rod, non-cone photoreceptor in the human eye that mediates a number of effects on the brain has sparked a growing interest in incorporating these non-visual effects of… Expand
Different colors of light lead to different adaptation and activation as determined by high-density EEG
TLDR
It is shown that the early EEG responses are differently affected by adaptation to different colors of light which may contribute to known differences in performance and reaction times in cognitive tests. Expand
Continuous coloured light altered human brain haemodynamics and oxygenation assessed by systemic physiology augmented functional near-infrared spectroscopy
TLDR
Effects of coloured light exposure on human systemic and brain physiology using systemic physiology augmented functional near-infrared spectroscopy (SPA-fNIRS) are determined and potentially of high relevance for choosing room lighting and may possibly be applied therapeutically. Expand
The Properties of our Everyday Spectral Microclimate
The CIE illuminant D65 is widely adopted as defining the standard spectral power distribution (SPD) for ‘average’ daylight. Thus daylight indoors is generally assumed to approximate the SPD for D65.… Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression
TLDR
It is demonstrated that humans are highly responsive to the phase‐delaying effects of light during the early biological night and that both the phase resetting response to light and the acute suppressive effect of light on plasma melatonin follow a logistic dose‐response curve, as do many circadian responses to light in mammals. Expand
Integration of human sleep-wake regulation and circadian rhythmicity.
TLDR
Findings on the physiological and molecular-genetic correlates of circadian sleep disorders suggest that the timing of the sleep-wake cycle and circadian rhythms is closely integrated but is, in part, regulated differentially. Expand
High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light.
TLDR
It is reported here that the circadian resetting response in humans, as measured by the pineal melatonin rhythm, is also wavelength dependent, and photopic lux, the standard unit of illuminance, is inappropriate when quantifying the photic drive required to reset the human circadian pacemaker. Expand
Photic Resetting of the Human Circadian Pacemaker in the Absence of Conscious Vision
TLDR
Light can affect the circadian pacemaker of some totally blind individuals— either by altering the phase of the circadianpacemaker or by affecting its amplitude, consistent with data from animal studies demonstrating that there are different neural pathways and retinal cells that relay photic information to the brain. Expand
Light Treatment for Sleep Disorders: Consensus Report
TLDR
In 1980, investigators at the National Institute of Mental Health reported that bright light could suppress melatonin production in humans, thereby demonstrating unequivocally the powerful effects of light on the human central nervous system. Expand
Getting Through to Circadian Oscillators: Why Use Constant Routines?
TLDR
It is argued that animal and human circadian rhythm researchers should (continue to) use constant routines as a step on the road to getting through to central and peripheral circadian oscillators in the intact organism. Expand
Adaptation of human pineal melatonin suppression by recent photic history.
TLDR
A significant increase in melatonin suppression during the stimulus after a prior photic history is found, revealing that humans exhibit adaptation of circadian photoreception and indicates that translation of a photic stimulus into drive on the human circadian pacemaker involves more complex temporal dynamics than previously recognized. Expand
Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans
TLDR
The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders. Expand
Photic Regulation of Melatonin in Humans: Ocular and Neural Signal Transduction
TLDR
Acute, light-induced suppression of melatonin is proving to be a powerful tool for clarifying how elements of ocular and neural physiology influence the interaction between light and the secretion ofmelatonin from the human pineal gland. Expand
Quantifying Human Circadian Pacemaker Response to Brief, Extended, and Repeated Light Stimuli over the Phototopic Range
TLDR
A new model in which a dynamic stimulus processor (Process L) intervenes between the light stimuli and the traditional representation of the circadian pacemaker as a self-sustaining limit-cycle oscillator is devised, generating a number of new testable hypotheses. Expand
...
1
2
3
...