Circadian Rhythm of Blood Pressure in Normotensive NIDDM Subjects: Its Relationship to Microvascular Complications

@article{Nakano1991CircadianRO,
  title={Circadian Rhythm of Blood Pressure in Normotensive NIDDM Subjects: Its Relationship to Microvascular Complications},
  author={Shigeru Nakano and K Uchida and Toshikazu Kigoshi and Sadahide Azukizawa and R Iwasaki and M Kaneko and Shinpei Morimoto},
  journal={Diabetes Care},
  year={1991},
  volume={14},
  pages={707 - 711}
}
Objective To investigate the relationship between circadian rhythm of mean blood pressure (MBP) and microvascular complications in non-insulin-dependent diabetes mellitus (NIDDM) subjects. Research Design and Methods Seventy-six normotensive NIDDM subjects without azotemia were studied under ordinary hospital conditions with a noninvasive ambulatory blood pressure monitoring device. Time series data were analyzed by the cosinor method. Results Fifty-four subjects had a circadian MBP rhythm… 

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References

SHOWING 1-10 OF 22 REFERENCES
Circadian variation of blood pressure in autonomic failure.
TLDR
A consistent circadian trend in blood pressure that was the inverse of the normal pattern, with the highest pressures at night and the lowest in the morning, was demonstrated in six subjects with autonomic failure who exhibited postural hypotension.
Loss of nocturnal decline in blood pressure after cardiac transplantation.
Twenty-four hour noninvasive ambulatory blood pressure and heart rate monitoring was performed on patients who underwent orthotopic cardiac transplantation, as part of the investigation of the de
Diabetic autonomic dysfunction, blood pressure, and sleep
TLDR
During rapid eye movement (REM) sleep, the Type I patients had abnormal systolic blood pressure measurements throughout the night, in sharp contrast to those in the other two groups, whose REM sleep–related blood pressure values were slightly above the preceding non‐REM sleep measurements.
Pressor Factors and Responsiveness in Hypertension Accompanying Diabetes Mellitus
TLDR
Sodium retention and cardiovascular hyperreactivity tend to occur even at the normotensive, nonazotemie stage of diabetes and may concomitantly predispose for the frequent development of hypertension in thediabetic population.
Incidence of Diabetic Retinopathy and Relationship to Baseline Plasma Glucose and Blood Pressure
TLDR
Lower rates of retinopathy development were observed during the follow-up period in diabetic patients on antihypertensive therapy at the baseline examination, suggesting that not only lower fasting plasma glucose and systolic blood pressure levels but also blood pressure therapy itself decreases the incidence of Retinopathy.
Twenty-four-hour blood pressure is not dependent on endogenous circadian rhythm.
TLDR
The immediate and complete adaptation of the 24-h blood pressure curve to shifted activity and sleeping phases indicates that activity determines the diurnal blood pressure profile.
Postprandial alterations in cardiovascular hemodynamics in autonomic dysfunction states.
Provocation of Postural Hypotension by Insulin in Diabetic Autonomic Neuropathy
TLDR
The effect of insulin administration on blood pressure has been investigated in eight diabetes with autonomic neuropathy, finding variations of postural hypotension recorded in some patients, the standing blood pressure falling with the onset of insulin action and rising again as the latter declines.
Diabetic orthostatic hypotension: the role of total exchangeable sodium and nephropathy.
TLDR
It is suggested that the presence of nephropathy markedly influences sodium balance in diabetics with OH and has a substantial influence on orthostatic BP and PRA responses.
...
1
2
3
...