Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review

  title={Circadian Rhythm Disturbances in Patients with Alzheimer's Disease: A Review},
  author={Dawit A. Weldemichael and George T Grossberg},
  booktitle={International journal of Alzheimer's disease},
Circadian Rhythm Disturbances (CRDs) affect as many as a quarter of Alzheimer's disease (AD) patients during some stage of their illness. Alterations in the suprachiasmatic nucleus and melatonin secretion are the major factors linked with the cause of CRDs. As a result, the normal physiology of sleep, the biological clock, and core body temperature are affected. This paper systematically discusses some of the causative factors, typical symptoms, and treatment options for CRDs in patients with… CONTINUE READING


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