Circadian Rhythm Disorders and Chronotherapy for Mood Disorders

  title={Circadian Rhythm Disorders and Chronotherapy for Mood Disorders},
  author={Sara Timtim and David K. Welsh},
Human circadian timing—most visibly, the sleep-wake cycle—is constantly calibrated to match changing environmental conditions, through a complex system that responds mainly to ambient light. For psychiatrists, the most familiar clinical manifestations of disordered circadian timing are sleep disorders, that is, impaired intrinsic circadian cycling or a persistent mismatch between an individual’s sleep timing and societal expectations, and this chapter discusses their psychopathology. However… Expand
1 Citations
Pills or Sleep Deprivation? Sleep-Deprivation as a Therapeutic Option Intervention in Psychiatry
The use of sleep deprivation in clinical conditions is aimed primarily at preventing depression and its recurrence, as well as in cases resistant to pharmacotherapy, and should be used under close supervision of a physician. Expand


Circadian rhythms and treatment implications in depression
The molecular and genetic mechanisms regulating the endogenous clock system are described, and the literature supporting the relationships between depression, antidepressant treatments and changes in circadian rhythms is reviewed. Expand
Visual impairment and circadian rhythm disorders
Many aspects of human physiology and behavior are dominated by 24-hour circadian rhythms that have a major impact on our health and well-being, including the sleep-wake cycle, alertness andExpand
The circadian basis of winter depression.
The findings support the phase-shift hypothesis for SAD, as well as suggest a way to assess the circadian component of other psychiatric, sleep, and chronobiologic disorders. Expand
Circadian Integration of Metabolism and Energetics
Advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes are reviewed and implications for rational therapeutics for these conditions are reviewed. Expand
Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects.
Results indicate that, in healthy young subjects, subjective mood is influenced by a complex and nonadditive interaction of circadian phase and duration of prior wakefulness, and the nature of this interaction is such that moderate changes in the timing of the sleep-wake cycle may have profound effects on subsequent mood. Expand
Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders
The findings suggest that delayed and disorganised circadian rhythms may be linked to worse psychiatric profiles in young people with depressive disorders. Expand
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons
It is shown, using an aberrant light cycle that neither changes the amount and architecture of sleep nor causes changes in the circadian timing system, that light directly regulates mood-related behaviours and cognitive functions in mice. Expand
Subjective Well-Being Is Modulated by Circadian Phase, Sleep Pressure, Age, and Gender
The results demonstrate age- and/or gender-related modifications of well-being related to sleep deprivation and circadian phase and thus point to specific biological components of mood vulnerability. Expand
Circadian rhythms and mood disorders: a guide for the perplexed.
  • A. Lewy
  • Psychology, Medicine
  • The Journal of clinical psychiatry
  • 2015
The dim light melatonin onset (DLMO) is now acknowledged as the most accurate biomarker for circadian phase position and is comprehensively useful in the diagnosis, and in all stages of treatment, of circadian rhythm disorders. Expand
Circadian abnormalities, molecular clock genes and chronobiological treatments in depression.
chronobiological augmentation using combinations of sleep deprivation with light therapy and/or sleep phase advance in medicated patients supports a clinical strategy for accelerating and sustaining antidepressant responses to circadian interventions. Expand