Circadian Regulation in the Ability of Drosophila to Combat Pathogenic Infections

@article{Lee2008CircadianRI,
  title={Circadian Regulation in the Ability of Drosophila to Combat Pathogenic Infections},
  author={Jung-Eun Lee and Isaac Edery},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={195-199}
}
We sought to determine if the innate immune response is under circadian regulation and whether this impacts overall health status. To this end, we used infection of Drosophila with the human opportunistic pathogenic bacteria Pseudomonas aeruginosa as our model system [1]. We show that the survival rates of wild-type flies vary as a function of when, during the day, they are infected, peaking in the middle of the night. Although this rhythm is abolished in clock mutant flies, those with an… CONTINUE READING

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