Circadian Polymorphisms in Night Owls, in Bipolars, and in Non-24-Hour Sleep Cycles

  title={Circadian Polymorphisms in Night Owls, in Bipolars, and in Non-24-Hour Sleep Cycles},
  author={Daniel F Kripke and Walter T. Klimecki and Caroline M. Nievergelt and Katharine M. Rex and Sarah S. Murray and Tatyana Shekhtman and Gregory J Tranah and Richard T. Loving and Heon-Jeong Lee and Min Kyu Rhee and Farhad F. Shadan and J. Steven Poceta and Shazia M Jamil and Lawrence E. Kline and John Kelsoe},
  booktitle={Psychiatry investigation},
People called night owls habitually have late bedtimes and late times of arising, sometimes suffering a heritable circadian disturbance called delayed sleep phase syndrome (DSPS). Those with DSPS, those with more severe progressively-late non-24-hour sleep-wake cycles, and those with bipolar disorder may share genetic tendencies for slowed or delayed circadian cycles. We searched for polymorphisms associated with DSPS in a case-control study of DSPS research participants and a separate study of… CONTINUE READING
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Chronotherapeutics for Affective Disorders: A Clinician’s Manual for Light and Wake Therapy

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