Circadian Oscillation of Sulfiredoxin in the Mitochondria.

@article{Kil2015CircadianOO,
  title={Circadian Oscillation of Sulfiredoxin in the Mitochondria.},
  author={In Sup Kil and Keun Woo Ryu and Se Kyoung Lee and Jeong Yeon Kim and Sei Yoon Chu and Ju Hee Kim and Sunjoo Park and Sue Goo Rhee},
  journal={Molecular cell},
  year={2015},
  volume={59 4},
  pages={
          651-63
        }
}
Hydrogen peroxide (H2O2) released from mitochondria regulates various cell signaling pathways. Given that H2O2-eliminating enzymes such as peroxiredoxin III (PrxIII) are abundant in mitochondria, however, it has remained unknown how such release can occur. Active PrxIII-SH undergoes reversible inactivation via hyperoxidation to PrxIII-SO2, which is then reduced by sulfiredoxin. We now show that the amounts of PrxIII-SO2 and sulfiredoxin undergo antiphasic circadian oscillation in the… CONTINUE READING
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Multiple Functions and Regulation of Mammalian Peroxiredoxins.

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The Circadian Nature of Mitochondrial Biology

  • Front. Endocrinol.
  • 2016
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Cellular Timekeeping: It's Redox o'Clock.

  • Cold Spring Harbor perspectives in biology
  • 2018
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References

Publications referenced by this paper.
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