Circadian Neuron Feedback Controls the Drosophila Sleep-Activity Profile

@inproceedings{Guo2016CircadianNF,
  title={Circadian Neuron Feedback Controls the Drosophila Sleep-Activity Profile},
  author={Fang Guo and Junwei Yu and Hyung Jae Jung and Katharine C Abruzzi and Weifei Luo and Leslie C. Griffith and Michael Rosbash},
  booktitle={Nature},
  year={2016}
}
Little is known about the ability of Drosophila circadian neurons to promote sleep. Here we show, using optogenetic manipulation and video recording, that a subset of dorsal clock neurons (DN1s) are potent sleep-promoting cells that release glutamate to directly inhibit key pacemaker neurons. The pacemakers promote morning arousal by activating these DN1s, implying that a late-day feedback circuit drives midday siesta and night-time sleep. To investigate more plastic aspects of the sleep… CONTINUE READING
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