Circadian Gene Expression in Individual Fibroblasts Cell-Autonomous and Self-Sustained Oscillators Pass Time to Daughter Cells

  title={Circadian Gene Expression in Individual Fibroblasts Cell-Autonomous and Self-Sustained Oscillators Pass Time to Daughter Cells},
  author={Emi Nagoshi and C. Saini and C. Bauer and T. Laroche and F. Naef and U. Schibler},
  • Emi Nagoshi, C. Saini, +3 authors U. Schibler
  • Published 2004
  • Biology, Medicine
  • Cell
  • The mammalian circadian timing system is composed of a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain and subsidiary oscillators in most peripheral cell types. [...] Key Method Using two reporter systems, we monitored circadian gene expression in NIH3T3 mouse fibroblasts in real time and in individual cells. In conjunction with mathematical modeling and cell co-culture experiments, these data demonstrated that in vitro cultured fibroblasts harbor self-sustained and cell-autonomous circadian…Expand Abstract
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