Circadian Disruption, Sleep Loss, and Low-Grade Inflammation

  title={Circadian Disruption, Sleep Loss, and Low-Grade Inflammation},
  author={R. Hardeland},
Circadian rhythmicity is a fundamental property of the majority of organisms, including bacteria, unicellular eukaryotes, fungi, plants and animals. It is generated by cellular oscillators and may have evolved to cope with adverse phases in the cycle of a day that bear the risk of damage by radiation and reactive metabolites, such as free radicals. In a complex organism like the human, the circadian system is composed of numerous, internally communicating, oscillators including a coordinating… Expand
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