Circadian Clocks in Mouse and Human CD4+ T Cells

  title={Circadian Clocks in Mouse and Human CD4+ T Cells},
  author={Thomas J Bollinger and Anton Leutz and Alexei Leliavski and Ludmila Skrum and Judit Kovac and Luigi Bonacina and Christian Benedict and Tanja Lange and J{\"u}rgen Westermann and Henrik Oster and W Solbach},
  booktitle={PloS one},
Though it has been shown that immunological functions of CD4+ T cells are time of day-dependent, the underlying molecular mechanisms remain largely obscure. To address the question whether T cells themselves harbor a functional clock driving circadian rhythms of immune function, we analyzed clock gene expression by qPCR in unstimulated CD4+ T cells and immune responses of PMA/ionomycin stimulated CD4+ T cells by FACS analysis purified from blood of healthy subjects at different time points… CONTINUE READING
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