Circadian Clocks: The Tissue Is the Issue

Abstract

The circadian clock uses a widely expressed pair of clock activators to drive tissue-specific rhythms in target gene expression. A new study sheds light on this tissue specificity by showing that binding of clock activators and tissue-specific transcription factors to closely associated target sites enables cooperative activation of target genes in different tissues.

DOI: 10.1016/j.cub.2013.11.016

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Cite this paper

@article{Menet2014CircadianCT, title={Circadian Clocks: The Tissue Is the Issue}, author={Jerome S. Menet and Paul E. Hardin}, journal={Current Biology}, year={2014}, volume={24}, pages={R25-R27} }