Circadian Clocks: Role in Health and Disease

  title={Circadian Clocks: Role in Health and Disease},
  author={Michelle L. Gumz},
  booktitle={Physiology in Health and Disease},
  • M. Gumz
  • Published in
    Physiology in Health and…
  • Biology
Circadian rhythms are rhythms in behavior, physiology, or metabolism with a cycle length of approximately 24 h. Environmental disruption of daily rhythms leads to adverse health consequences, both in animal models and in humans engaged in shift work. The light–dark cycle has a major “entraining” influence on rhythms. Light for circadian entrainment is detected by rods, cones, and a population of intrinsically photosensitive retinal ganglion cells. The suprachiasmatic nuclei (SCN) generate and… 

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