Circadian Clock's Cancer Connections

  title={Circadian Clock's Cancer Connections},
  author={Zandra E. Walton and Brian J. Altman and Rebekah Brooks and Chi Van Dang},
The circadian molecular clock regulates and coordinates cellular metabolism with the organism's daily feeding and fasting cycle. Disruption of circadian rhythm, such as through jet lag or shift work, appears to heighten cancer risk in humans and accelerates tumorigenesis in animal models. The mammalian clock is a circuitry of transcription factors anchored by BMAL1-CLOCK, which drives diurnal oscillation of metabolic gene expression. The clock is independent of the cell cycle, but they can… 

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