Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression.

@article{Kalamvoki2010CircadianCH,
  title={Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression.},
  author={Maria Kalamvoki and Bernard Roizman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 41},
  pages={17721-6}
}
Expression of herpes simplex virus genes at the initiation of replication involves two steps that take place at ND10 nuclear bodies. These are suppression of cellular repressors that attempt to silence viral DNA and remodeling of the viral chromatin to make it accessible for transcription. In earlier studies we reported on the mechanism by which viral proteins ICP0 and U(S)3 protein kinase modify and disrupt the HDAC1/CoREST/REST/LSD1 repressor complex. The remodeling step requires in addition… CONTINUE READING

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