Ciprofloxacin and sparfloxacin penetration into human brain tissue and their activity as antagonists of GABAA receptor of rat vagus nerve.

@article{Davey1994CiprofloxacinAS,
  title={Ciprofloxacin and sparfloxacin penetration into human brain tissue and their activity as antagonists of GABAA receptor of rat vagus nerve.},
  author={Peter Garnet Davey and Muskegon Charter and Stephen Kelly and Tk. Varma and Izhak Jacobson and Arnold James Freeman and E. Precious and Jean Pierre Lambert},
  journal={Antimicrobial agents and chemotherapy},
  year={1994},
  volume={38 6},
  pages={
          1356-62
        }
}
Patients undergoing elective surgery for removal of brain tumors, aneurysms, or other vascular malformations were administered a single oral dose of sparfloxacin (400 mg; 16 patients) or ciprofloxacin (750 mg; 5 patients) either 3 to 5 h or 22 to 26 h before surgery. Serum samples were taken from all patients at 0, 1, 3 to 5, 7 to 9, and 22 to 26 h after dosing; an additional serum sample was obtained at 48 h from patients who received sparfloxacin. A single sample of brain tissue was taken… CONTINUE READING
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