Ciprofloxacin accelerates aortic enlargement and promotes dissection and rupture in Marfan mice.

@article{Lemaire2020CiprofloxacinAA,
  title={Ciprofloxacin accelerates aortic enlargement and promotes dissection and rupture in Marfan mice.},
  author={Scott Lemaire and Lin Zhang and Na Zhang and Wei Luo and James P. Barrish and Qianzi Zhang and Joseph S. Coselli and Ying H. Shen},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2020}
}
8 Citations
Reply
Commentary: Danger of fluoroquinolones in Marfan syndrome.
  • M. Si
  • Medicine
    The Journal of thoracic and cardiovascular surgery
  • 2020
Commentary: Fluoroquinolone antibiotics are antiaortic.
Commentary: Fluoroquinolone guilt: The evidence mounts.

References

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Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice
TLDR
Ciprofloxacin increases susceptibility to aortic dissection and rupture in a mouse model of moderate, sporadic AAD and should be used with caution in patients with aorti dilatation, as well as in those at high risk for AAD.
AKT2 Confers Protection Against Aortic Aneurysms and Dissections
TLDR
Evidence is provided of a mechanism that underlies the protective effects of AKT2 on the aortic wall and that may serve as a therapeutic target in the prevention of AAD.
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice
TLDR
Findings indicate that ADAMTS-4 induces SMC apoptosis, degrades versican, promotes inflammatory cell infiltration, and thus contributes to sporadic AAD development.
Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone.
TLDR
Use of fluoroquinolones was associated with an increased risk of aortic aneurysm and dissection, and physicians should be aware of this possible drug safety risk associated with fluoroquolone therapy.
Thoracic Aortic Dissection: Are Matrix Metalloproteinases Involved?
TLDR
This article reviews the recent literature and summarizes the current understanding of the role of MMPs in the pathobiology of thoracic aortic dissection, and suggests that inhibition of M MPs may be beneficial in reducing MMP-mediated aorta damage associated with dissection.
Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study
TLDR
In a propensity score matched cohort, fluoroquinolone use was associated with an increased risk of aortic aneurysm or dissection, and this association appeared to be largely driven by aorto- dissection.
TGF-β–dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome
Mitral valve prolapse (MVP) is a common human phenotype, yet little is known about the pathogenesis of this condition. MVP can occur in the context of genetic syndromes, including Marfan syndrome
Oral Fluoroquinolone and the Risk of Aortic Dissection.
Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans
TLDR
It is shown that a missense mutation in LOX causes aortic aneurysm and dissection because of insufficient elastin and collagen cross-linking in the aorta wall, confirming mutations in LOZ as a cause of aorti disease in humans and identifying LOX as a diagnostic and potentially therapeutic target.
Patients at Risk for Aortic Rupture Often Exposed to Fluoroquinolones during Hospitalization
TLDR
Reducing fluoroquinolone use in hospitalized patients with aortic disorders will become an urgent safety issue for antibiotic stewardship programs if the deleterious effects of fluoroquolone on aorta integrity are substantiated.
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