Cinnarizine‐induced parkinsonism: Ten years later

  title={Cinnarizine‐induced parkinsonism: Ten years later},
  author={Jos{\'e}-F{\'e}lix Mart{\'i}-Mass{\'o} and Juan Jos{\'e} Poza},
  journal={Movement Disorders},
A retrospective study was carried out to investigate the evolution of patients diagnosed with cinnarizineinduced parkinsonism (CIP) over the past 15 years. A total of 74 cases of CIP were found among 172 patients with druginduced parkinsonism (DIP). Both CIP and other DIP were significantly more frequent in women. No clinical differences between CIP and other DIP were found. Most of the patients (66 of 74) completely recovered after cinnarizine withdrawal in 1–16 months. Eleven patients later… 

Cinnarizine‐induced parkinsonism: Ten years later

  • A. NegrottiS. Calzetti
  • Medicine, Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 1999
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Though controlled epidemiological studies are needed to evaluate the possibility that cinnarizine is increasingly prescribed in the general population with advancing age, data suggests that aging plus a background of genetically determined essential tremor represented critical risk factors for development of this drug side effect.

Movement disorders and depression due to flunarizine and cinnarizine

Whether or not such undesirable side effects are attributable to calcium antagonism and/or dopamine receptor blockade, long‐term treatment with flunarizine or cinnarIZine should be discouraged, particularly in the elderly.

Parkinsonism Associated With Calcium Channel Blockers: A Prospective Follow‐up Study

It is indicated that CCB-induced parkinsonism is not the benign condition previously thought, and an age-related prognosis of this entity is suggested, and this entity's long-term evolution is unknown.

Cinnarizine-induced parkinsonism in primates.

The production of an experimental model of parkinsonism induced by cinnarizine (CNZ) in three healthy sylvanna monkeys suggests a predominant presynaptic effect on DA and 5-HT neurons; and could account for the longstanding parkinsonistan induced by calcium antagonist in some patients as well as the depression observed in these subjects.

Coexistence of severe parkinsonism and tardive dyskinesia as side effects of neuroleptic therapy.

It is hypothesized that the coexistence of these two opposing side effects is due to simultaneous blockade and supersensitivity of two different subclasses of striatal dopaminergic receptors.

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