Cinnarizine‐induced parkinsonism: Ten years later

@article{MartMass1998CinnarizineinducedPT,
  title={Cinnarizine‐induced parkinsonism: Ten years later},
  author={Jos{\'e}-F{\'e}lix Mart{\'i}-Mass{\'o} and Juan Jos{\'e} Poza},
  journal={Movement Disorders},
  year={1998},
  volume={13}
}
A retrospective study was carried out to investigate the evolution of patients diagnosed with cinnarizineinduced parkinsonism (CIP) over the past 15 years. A total of 74 cases of CIP were found among 172 patients with druginduced parkinsonism (DIP). Both CIP and other DIP were significantly more frequent in women. No clinical differences between CIP and other DIP were found. Most of the patients (66 of 74) completely recovered after cinnarizine withdrawal in 1–16 months. Eleven patients later… 

Cinnarizine‐induced parkinsonism: Ten years later

  • A. NegrottiS. Calzetti
  • Medicine, Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 1999
CIP accounts for a high proportion of DIP referred to neurologists in populations in which cinnarizine is widely prescribed, and the symptoms typically resolve after drug withdrawal, although complete recovery may take more than 1 year.

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A clinical review

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The epidemiology, pathogenic mechanisms, implicated drugs, clinical features and management of drug-induced parkinsonism are reviewed and the need for increased awareness of this iatrogenic condition is highlighted.

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It is speculated that the possible neurotoxic effect of neuroleptics exerted on a susceptible dopaminergic system would lead over the long‐term to a self‐fostering, progressive process.

Drug-Induced Parkinsonism

DIP may have a significant and longstanding effect on patients' daily lives, and so physicians should be cautious when prescribing dopaminergic receptor blockers and should monitor patients' neurological signs, especially for parkinsonism and other movement disorders.

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