Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress.

@article{Wondrak2008CinnamoylbasedNT,
  title={Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress.},
  author={Georg Thomas Wondrak and Christopher M. Cabello and Nicole F. Villeneuve and Shirley Zhang and Stephanie Ley and Yanjie Li and Zheng Sun and Donna D. Zhang},
  journal={Free radical biology & medicine},
  year={2008},
  volume={45 4},
  pages={385-95}
}
Strong experimental evidence suggests the involvement of photo-oxidative stress mediated by reactive oxygen species as a crucial mechanism of solar damage relevant to human skin photoaging and photocarcinogenesis. Based on the established role of antioxidant response element (ARE)-mediated gene expression in cancer chemoprevention, we tested the hypothesis that small molecule Nrf2-activators may serve a photo-chemopreventive role by targeting skin cell photo-oxidative stress. A luciferase-based… CONTINUE READING

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The basal layer in human squamous tumors harbors more UVA than tivators targeting human skin cell photo-oxidative stress, Free Radic

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