Cinnamon: A systematic review of adverse events.

@article{Hajimonfarednejad2019CinnamonAS,
  title={Cinnamon: A systematic review of adverse events.},
  author={Mahdie Hajimonfarednejad and Mohadeseh Ostovar and Mohammad Javad Raee and M. H. Hashempur and Johannes Gottfried Mayer and Mojtaba Heydari},
  journal={Clinical nutrition},
  year={2019},
  volume={38 2},
  pages={
          594-602
        }
}
Cinnamon, from the genus Cinnamomum and Lauraceae family, has been used as a popular spice for thousands of years around the world. Many studies have shown therapeutic effects of cinnamon including its antimicrobial, antiviral, antifungal, antioxidant, antitumor, antihypertensive, antilipemic, antidiabetic, gastroprotective, and immunomodulatory effects. Due to popular use of cinnamon and several human reports on adverse events associated with short or long term use of cinnamon, we aimed to… 
Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis.
TLDR
It is indicated that cinnamon supplementation may help polycystic ovary syndrome patients to manage their metabolic parameters and an improvement of serum concentration of HDL-C was shown by cinnamon supplementation.
Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits
TLDR
This comprehensive and updated review of the biodiversity of the genus Cinnamomum, its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety, and the obtained results from preclinical studies and clinical trials provide insights into future research of new drugs based on extracts andBioactive compounds from Cinnemomum plants.
Current Knowledge of Cinnamomum Species: A Review on the Bioactive Components, Pharmacological Properties, Analytical and Biotechnological Studies
TLDR
The recent relevant scientific evidence on the botanic characterization, distribution, traditional uses, pharmacological activities, phytochemistry, qualitative and quantitative estimation and extraction of important secondary metabolites, genetic diversity assessment, biotechnological breakthroughs, cultivation, and propagation are summarized to assess future perspectives for Cinnamon as a pharmacologically leading genus of interest.
Phytochemical and pharmacological review of Cinnamomum verum J. Presl-a versatile spice used in food and nutrition.
TLDR
Cinnamomum verum is the widely used spice for its medicinal and culinary uses since ages and its comprehensive and up-to-date information on taxonomy, ethnomedicinal uses, phytochemical composition, pharmacological and toxicity activities is highlighted.
In vitro examination of antibacterial and immunomodulatory activities of cinnamon, white thyme, and clove essential oils
TLDR
Results support the potential use of essential oils in the food industry for their antimicrobial and immunomodulatory effects; however, the underlying mechanisms are unknown and warrant further research.
Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review
TLDR
Garlic, ginger, cinnamon, and saffron supplementation could have a beneficial effect on RA activity, but the risk of bias of these studies is difficult to assess and data are too limited to recommend them in daily practice.
The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials.
TLDR
The present meta-analysis suggests that cinnamon supplementation can improve blood pressure by a modest degree, however, due to limited availability of studies with hypertensive cases and relatively small sample sizes of available studies, well designed trials with adequate sample sizes aimed at hypertensive populations are recommended.
The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials.
TLDR
Cinnamon supplementation had no significant effect on liver enzymes in adults, however, the effect of cinnamon on ALT levels was significant at the dosages of <1500 mg/day, in trials lasting>12 weeks, and in trials conducted of both gender.
Natural Compounds With Antibacterial Activity Against Cronobacter spp. in Powdered Infant Formula: A Review
TLDR
The present review provides a comprehensive summary of currently available data pertaining to the antibacterial effects of natural antimicrobial compounds against Cronobacter spp.
Impact of Cinnamon Supplementation on cardiometabolic Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
TLDR
Cinnamon supplementation may be an adjuvant for reducing inflammation and oxidative stress levels in humans.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 96 REFERENCES
Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review
TLDR
The available in-vitro and in-Vivo evidence suggests that CZ has many beneficial health effects, however, since data on humans are sparse, randomized controlled trials in humans will be necessary to determine whether these effects have public health implications.
Bioactivity of cinnamon with special emphasis on diabetes mellitus: A review
TLDR
The necessity of evaluating the effects of cinnamon for its therapeutic potential through well-defined and adequately powered randomized controlled clinical trials is emphasized, before recommendations are made for the use of cinnamon as an effective treatment for humans.
Beneficial Effects of Cinnamon on the Metabolic Syndrome, Inflammation, and Pain, and Mechanisms Underlying These Effects – A Review
TLDR
An overview of the recent literature describing cinnamon's potential for preventing the metabolic syndrome is provided.
The Effect of Cinnamon on Menstrual Bleeding and Systemic Symptoms With Primary Dysmenorrhea
TLDR
Cinnamon can be regarded as a safe and effective treatment for dysmenorrhea in young women with significant effect on reduction of pain, menstrual bleeding, nausea and vomiting with primary dys menorrhea without side effects.
Cinnamon: A Multifaceted Medicinal Plant
  • P. Rao, S. Gan
  • Medicine
    Evidence-based complementary and alternative medicine : eCAM
  • 2014
TLDR
Cinnamon is one of the most important spices used daily by people all over the world and is reported to have activities against neurological disorders, such as Parkinson's and Alzheimer's diseases.
Cinnamon effects on metabolic syndrome: a review based on its mechanisms
TLDR
Investigation of the mechanisms of C. verum and its active ingredients indicated that cinnamon has protective effects against MetS’s aspects in various ways and the use of this plant can be effective in reducing MetS's complications and its morbidity and mortality.
The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials
TLDR
Cinnamon has the potential to be a useful add-on therapy in the discipline of integrative medicine in managing type 2 diabetes, but at present the evidence is inconclusive and long-term trials aiming to establish the efficacy and safety of cinnamon is needed.
Comparative effect of cinnamon and Ibuprofen for treatment of primary dysmenorrhea: a randomized double-blind clinical trial.
TLDR
Cinnamon compared with placebo significantly reduced the severity and duration of pain during menstruation, but this effect was lower compared with Ibuprofen.
The effects of cinnamon supplementation on blood lipid concentrations: A systematic review and meta-analysis.
TLDR
Cinnamon supplementation significantly reduced blood triglycerides and total cholesterol concentrations without any significant effect on LDL-C and HDL-C while positively associated with the duration of supplementation.
Severe exacerbation of rosacea induced by cinnamon supplements.
TLDR
A 68-year-old Caucasian female with type 2 diabetes mellitus who experienced an acute exacerbation of her rosacea 2 weeks after self-initiating cinnamon oil pills to lower her blood sugar levels is reported.
...
1
2
3
4
5
...