Cinnamic compound metabolism in human skin and the role metabolism may play in determining relative sensitisation potency.

@article{Cheung2003CinnamicCM,
  title={Cinnamic compound metabolism in human skin and the role metabolism may play in determining relative sensitisation potency.},
  author={Connie Cheung and Sharon A M Hotchkiss and Camilla K Smith Pease},
  journal={Journal of dermatological science},
  year={2003},
  volume={31 1},
  pages={9-19}
}
BACKGROUND trans-Cinnamaldehyde and trans-cinnamic alcohol cause allergic contact dermatitis (ACD) in humans; cinnamaldehyde is a more potent sensitiser than cinnamic alcohol. These two chemicals are principal constituents of the European Standard 'Fragrance Mix', as used in patch testing diagnostics of sensitisation to fragrances by clinical dermatologists. As contact sensitisers are usually protein reactive compounds, it is hypothesised that cinnamic alcohol (not protein-reactive) is a… CONTINUE READING