Cinnamic acid amides from Tribulus terrestris displaying uncompetitive α-glucosidase inhibition.

@article{Song2016CinnamicAA,
  title={Cinnamic acid amides from Tribulus terrestris displaying uncompetitive α-glucosidase inhibition.},
  author={Yeong Hun Song and Dae Wook Kim and Marcus John Curtis-Long and Chanin Park and Minky Son and Jeong Yoon Kim and Heung Joo Yuk and Keun Woo Lee and Ki Hun Park},
  journal={European journal of medicinal chemistry},
  year={2016},
  volume={114},
  pages={
          201-8
        }
}
The α-glucosidase inhibitory potential of Tribulus terrestris extracts has been reported but as yet the active ingredients are unknown. This study attempted to isolate the responsible metabolites and elucidate their inhibition mechanism of α-glucosidase. By fractionating T. terristris extracts, three cinnamic acid amide derivatives (1-3) were ascertained to be active components against α-glucosidase. The lead structure, N-trans-coumaroyltyramine 1, showed significant inhibition of α-glucosidase… CONTINUE READING

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