Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.

  title={Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.},
  author={Woo Seok Koh and Sun Young Yoon and Bumi Kwon and Tae Cheon Jeong and Kyung Soo Nam and Mi Young Han},
  journal={International journal of immunopharmacology},
  volume={20 11},
Two kinds of cinnamaldehyde derivative, 2'-hydroxycinnamaldehyde (HCA) and 2'-benzoxy-cinnamaldehyde (BCA), were studied for their immunomodulatory effects. These compounds were screened as anticancer drug candidates from stem bark of Cinnamomum cassia for their inhibitory effect on farnesyl protein transferase activity. Ras activation, which is accompanied with its farnesylation, has been known to be important in immune cell activation as well as in carcinogenesis. Treatment of these… CONTINUE READING


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