Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.

@article{Koh1998CinnamaldehydeIL,
  title={Cinnamaldehyde inhibits lymphocyte proliferation and modulates T-cell differentiation.},
  author={Woo Suk Koh and S. Y. Yoon and Byoung-Mog Kwon and Tae Cheon Jeong and Kyung Soo Nam and M Y Han},
  journal={International journal of immunopharmacology},
  year={1998},
  volume={20 11},
  pages={
          643-60
        }
}
  • W. Koh, S. Yoon, +3 authors M. Y. Han
  • Published 1998
  • Biology, Medicine
  • International journal of immunopharmacology
Two kinds of cinnamaldehyde derivative, 2'-hydroxycinnamaldehyde (HCA) and 2'-benzoxy-cinnamaldehyde (BCA), were studied for their immunomodulatory effects. These compounds were screened as anticancer drug candidates from stem bark of Cinnamomum cassia for their inhibitory effect on farnesyl protein transferase activity. Ras activation, which is accompanied with its farnesylation, has been known to be important in immune cell activation as well as in carcinogenesis. Treatment of these… Expand
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  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2008
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  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2004
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Antiproliferative Activity of Cinnamomum cassia Constituents and Effects of Pifithrin-Alpha on Their Apoptotic Signaling Pathways in Hep G2 Cells
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  • Medicine
  • Evidence-based complementary and alternative medicine : eCAM
  • 2011
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It is indicated that Cin was the most potent antiproliferative constituent of C. cassia, and its apoptotic mechanism in Hep G2 cells could be mediated through the p53 induction and CD95 (APO-1) signaling pathways. Expand
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Results suggest that TCA may be a useful chemotherapeutic agent for cancer treatment in human by cell cycle analysis and inhibitory effects of TCA against selected human cancer cell lines. Expand
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