Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells.

@article{Ka2003CinnamaldehydeIA,
  title={Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells.},
  author={Hyeon Ka and H Park and Hyun-Ju Jung and Jong-Won Choi and Kyu-Seok Cho and Joohun Ha and Kyung-Tae Lee},
  journal={Cancer letters},
  year={2003},
  volume={196 2},
  pages={143-52}
}
Cinnamaldehyde is an active compound isolated from the stem bark of Cinnamomum cassia, a traditional oriental medicinal herb, which has been shown to inhibit tumor cell proliferation. In this study, we investigated the effects of cinnamaldehyde on the cytotoxicity, induction of apoptosis and the putative pathways of its actions in human promyelocytic leukemia cells. Using apoptosis analysis, measurement of reactive oxygen species (ROS), and assessment of mitochondrial membrane potentials… CONTINUE READING
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