Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds.

@article{AlarcndelaLastraRomero1997CinitapridePA,
  title={Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds.},
  author={C Alarc{\'o}n-de-la-Lastra Romero and A. L{\'o}pez and M. D. J. Martin and Carmen La Casa and Virginia Motilva},
  journal={Pharmacology},
  year={1997},
  volume={54 4},
  pages={
          193-202
        }
}
This study was designed to determine the gastroprotective properties of cinitapride (CNT), a novel prokinetic benzamide derivative agonist of 5-HT4 and 5-HT1 receptors and 5-HT2 antagonist, on mucosal injury produced by 50% (v/v) ethanol. Results were compared with those for 5-hydroxytryptamine (5-HT: 10 mg kg-1). The possible involvements of gastric mucus secretion, endogenous prostaglandins (PGs) and sulfhydryl compounds (SH) in the protection mediated by CNT were also examined… 
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