Cingulate gyrus volume and metabolism in the schizophrenia spectrum

@article{Haznedar2004CingulateGV,
  title={Cingulate gyrus volume and metabolism in the schizophrenia spectrum},
  author={M. Mehmet Haznedar and Monte S. Buchsbaum and Erin A. Hazlett and Lina Shihabuddin and Antonia S. New and Larry J. Siever},
  journal={Schizophrenia Research},
  year={2004},
  volume={71},
  pages={249-262}
}
BACKGROUND The cingulate gyrus, which is involved in affect, attention, memory and higher executive functions, has been implicated as a dysfunctional region in schizophrenia. Postmortem studies report cytoarchitectural changes in the anterior cingulate gyrus (ACG) and functioning imaging studies show correlations between the degree of hypometabolism of the anterior cingulate and clinical symptoms in schizophrenia. METHODS Unmedicated patients with schizophrenia (n=27) and schizotypal… 
Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia
TLDR
Rostral ACC energy hypo-metabolism, possibly arising from neurodevelopmental processes, is associated with working memory impairment in schizophrenia, and changes in the rostral (not the expected caudal) subregion underscore the interconnections between the ACC subregions.
In-vivo topography of structural alterations of the anterior cingulate in patients with schizophrenia: New findings and comparison with the literature
TLDR
The hypothesis that different subregions of the anterior cingulate cortex are differentially affected by the disease process of schizophrenia, a circumstance that might contribute to contradictory results of earlier structural ACC studies, was examined.
Anterior cingulate pathology and social cognition in schizophrenia: A study of gray matter, white matter and sulcal morphometry
TLDR
Results suggested that pathology of the ACC, anterior cingulum and PCS/CS is, at least partially, independent and has differential impacts on psychopathology and social cognitive impairment in schizophrenia.
Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology.
TLDR
Structural neuroimaging and neuropathological studies of the anterior cingulate cortex are reviewed, focusing on the unique information they provide and the potential mechanisms that might facilitate integration of these findings and consider strategies for future research.
Diffusion tensor anisotropy in the cingulate gyrus in schizophrenia
It has been proposed that schizophrenia results partly from altered brain connectivity. The anterior cingulate cortex in particular has been demonstrated to be affected in schizophrenia, with studies
Abnormalities of cingulate cortex in antipsychotic-naïve chronic schizophrenia
TLDR
The results suggest that abnormalities in the cingulate cortex as manifested by reduced surface area may contribute to cognitive dysfunction in schizophrenia.
Evidence for neuronal dysfunction in the anterior cingulate of patients with schizophrenia: A proton magnetic resonance spectroscopy study at 3 T
TLDR
Schizophrenia patients had lower NAA concentrations throughout the dorsal and rostral portions of the anterior cingulate and in both hemispheres, but showed no changes in Glx.
Does hypofrontality expand to global brain area in progression of schizophrenia?: A cross-sectional study between first-episode and chronic schizophrenia
TLDR
The present study suggested that the reduction in rCBF occurs in the posterior brain area in addition to the frontal lobe across all clinical stages of schizophrenia.
Correlations between MRI-assessed volumes of the thalamus and cortical Brodmann's areas in schizophrenia
TLDR
Whereas patients with schizophrenia exhibit deficiencies in cortical-thalamic correlational patterns, poor outcome is associated with abnormal interregional correlations not observed in either normal subjects or patients with good outcomes.
Anterior cingulate volumes in schizophrenia: A systematic review and a meta-analysis of MRI studies
TLDR
This work confirmed the presence of abnormally reduced anterior cingulate volumes in schizophrenia, and demonstrated that the effect size was significantly related only to slice thickness.
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