Cingulate gyrus volume and metabolism in the schizophrenia spectrum

  title={Cingulate gyrus volume and metabolism in the schizophrenia spectrum},
  author={M. Mehmet Haznedar and Monte S. Buchsbaum and Erin A. Hazlett and Lina Shihabuddin and Antonia S. New and Larry J. Siever},
  journal={Schizophrenia Research},

Hypo-metabolism of the rostral anterior cingulate cortex associated with working memory impairment in 18 cases of schizophrenia

Rostral ACC energy hypo-metabolism, possibly arising from neurodevelopmental processes, is associated with working memory impairment in schizophrenia, and changes in the rostral (not the expected caudal) subregion underscore the interconnections between the ACC subregions.

Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology.

Structural neuroimaging and neuropathological studies of the anterior cingulate cortex are reviewed, focusing on the unique information they provide and the potential mechanisms that might facilitate integration of these findings and consider strategies for future research.

Abnormalities of cingulate cortex in antipsychotic-naïve chronic schizophrenia




Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging.

Compared with age- and sex-matched healthy volunteers, patients with autism spectrum disorders showed significantly decreased metabolism in both the anterior and posterior cingulate gyri.

Anterior cingulate gyrus volume and glucose metabolism in autistic disorder.

Autism may be characterized by structural and functional alterations in the anterior cingulate gyrus, and both area 24 and area 24' were metabolically less active, in the autistic patients than in the normal subjects.

Volume of the cingulate and outcome in schizophrenia

Volumetric analysis of the pre-frontal regions: findings in aging and schizophrenia

Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder

The results suggest that both schizotypal and schizophrenic subjects share, at least in part, the same cerebral asymmetry abnormalities.

Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial Stroop task performance.

Patients with schizophrenia fail to activate the anterior cingulate gyrus during selective attention performance, adding to the understanding of the functional significance of the structural and metabolic abnormalities in schizophrenia that have been previously reported in this region of the brain.

Evidence for abnormal cortical functional connectivity during working memory in schizophrenia.

Pronounced disruptions of distributed cooperative activity in schizophrenia were found and a pattern showing disturbed frontotemporal interactions showed promise as a trait marker and may be useful for future investigations.

A computational morphometric MRI study of schizophrenia: effects of hallucinations.

MRI data confirm the utility of voxel-based morphometric methods in schizophrenia research and point towards disruption to a 'paralimbic' neural network, as underlying schizophrenic psychopathology in general, with abnormalities of the left insula specifically related to hallucinations.