Cinacalcet in Pediatric and Adolescent Chronic Kidney Disease

  title={Cinacalcet in Pediatric and Adolescent Chronic Kidney Disease},
  author={Abdulla A. Alharthi and Naglaa Mohamed Kamal and Mohamed W. Abukhatwah and Laila Metwaly Sherief and Muhammed Mubarak.},
Cinacalcet, a calcimimetic drug, has been shown to be efficacious in adult chronic kidney disease (CKD) patients; however, it was not fully studied in pediatric CKD patients. We aimed at assessing the effect of cinacalcet on intact parathyroid hormone (iPTH) secretion in children with CKD-4/5 with iPTH consistently ≥ 300 pg/mL refractory to conventional treatment. This is a prospective cohort analysis of 28 children with uncontrolled hyper-parathyroidism secondary to stage 4 and 5 CKD admitted… CONTINUE READING


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