Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism.

@article{Peacock2005CinacalcetHM,
  title={Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism.},
  author={Munro Peacock and John P. Bilezikian and Preston S Klassen and Matthew D Guo and Stewart A Turner and Dolores Marie Shoback},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 1},
  pages={135-41}
}
Calcimimetics increase the sensitivity of parathyroid calcium-sensing receptors to extracellular calcium, thereby reducing PTH secretion. This multicenter, randomized, double-blind, placebo-controlled study assessed the ability of the oral calcimimetic cinacalcet HCl to achieve long-term reductions in serum calcium and PTH concentrations in patients with primary hyperparathyroidism (HPT). Patients (n = 78) were randomized to cinacalcet or placebo. Cinacalcet was titrated from 30-50 mg twice… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 20 references

The effects of cinacalcet HCl (AMG 073) on serum calcium levels in patients with parathyroid carcinoma or recurrent primary hyperparathyroidism after parathyroidectomy

SJ Silverberg, JP Faiman, +6 authors M Peacock
J Bone Miner Res • 2003
View 1 Excerpt

Clinical presentation of primary hyperparathyroidism in Europe--nationwide cohort analysis on mortality from nonmalignant causes.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2002
View 1 Excerpt

Normalization of hypercalcemia with calcimimetic AMG 073 in a patient with metastatic parathyroid cancer

M Peacock
J Bone Miner Res • 2002
View 1 Excerpt

Primary hyperparathyroidism and the kidney: biochemical and clinical spectrum.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2002
View 1 Excerpt

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