Cinacalcet HCl Suppresses Cyclin D1 Oncogene-Derived Parathyroid Cell Proliferation in a Murine Model for Primary Hyperparathyroidism

@article{Imanishi2011CinacalcetHS,
  title={Cinacalcet HCl Suppresses Cyclin D1 Oncogene-Derived Parathyroid Cell Proliferation in a Murine Model for Primary Hyperparathyroidism},
  author={Yasuo Imanishi and Takehisa Kawata and Takao Kenko and Michihito Wada and Nobuo Nagano and Takami Miki and Andrew D. Arnold and Masaaki Inaba},
  journal={Calcified Tissue International},
  year={2011},
  volume={89},
  pages={29-35}
}
  • Yasuo Imanishi, Takehisa Kawata, +5 authors Masaaki Inaba
  • Published in
    Calcified Tissue…
    2011
  • Medicine, Biology
  • Cinacalcet HCl (cinacalcet) is a calcimimetic compound, which suppresses parathyroid (PTH) hormone secretion from parathyroid glands in both primary hyperparathyroidism (PHPT) and secondary hyperparathyroidism (SHPT). We previously reported the suppressive effect of cinacalcet on PTH secretion in vivo in a PHPT model mouse, in which parathyroid-targeted overexpression of the cyclinD1 oncogene caused chronic biochemical hyperparathyroidism and parathyroid cell hyperplasia. Although cinacalcet… CONTINUE READING

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    Parathyroid Diseases and Animal Models

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