Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis.

@article{Tian2007CimicifugaFE,
  title={Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis.},
  author={Ze Tian and Ruile Pan and Qi Chang and Jianyong Si and Peigen Xiao and Erxi Wu},
  journal={Journal of ethnopharmacology},
  year={2007},
  volume={114 2},
  pages={227-33}
}
The purpose of this study is to determine whether the ethyl acetate fraction (EAF) from the aerial part of Cimicifuga foetida Linnaeus possesses the anti-tumor action on hepatoma, and therefore, provide evidence for the traditional use of the plant as a detoxification agent. EAF was extracted and its cytotoxicity was evaluated on a panel of Hepatocytes by MTT assay. The IC(50) values of EAF on HepG2, R-HepG2 and primary cultured normal mouse hepatocytes were 21, 43 and 80 microg/mL… CONTINUE READING

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