Cimetidine therapy for gastroesophageal reflux disease.

  title={Cimetidine therapy for gastroesophageal reflux disease.},
  author={A P Archambault and A L Farley and Iain G. M. Cleator and Noel B Hershfield and Henri Navert and E. J. Prokipchuk and Alan B. R. Thomson},
  journal={The Western journal of medicine},
  volume={143 5},
In a Canadian multicenter trial, a new dosing regimen of cimetidine (Tagamet)-600 mg given twice a day-was compared with the standard regimen of 300 mg four times a day in 118 evaluable patients with endoscopically proved esophagitis. More than 90% of the patients evaluated had clinically moderate to severe esophagitis. After four weeks of therapy, both regimens had significantly reduced the number of episodes and the severity and duration of the worst episodes of daytime and nighttime… CONTINUE READING