Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells.

@article{Zheng2013CimetidineSL,
  title={Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells.},
  author={Yisheng Zheng and Meng Xu and Xiao Li and Jinpeng Jia and Kexing Fan and Guoxiang Lai},
  journal={Molecular immunology},
  year={2013},
  volume={54 1},
  pages={74-83}
}
Cimetidine, a histamine type-2 receptor antagonist, is known to inhibit the growth of several tumors in human and animals, however the mechanism of action underlying this effect remains largely unknown. Here, in the mice model of 3LL lung tumor, cimetidine showed significant inhibition of tumor growth. However, an in vitro study demonstrated that cimetidine… CONTINUE READING