Cimetidine in colorectal cancer – are the effects immunological or adhesion-mediated?

@article{Eaton2002CimetidineIC,
  title={Cimetidine in colorectal cancer – are the effects immunological or adhesion-mediated?},
  author={David Eaton and Robert Edward Hawkins},
  journal={British Journal of Cancer},
  year={2002},
  volume={86},
  pages={159 - 160}
}
In this issue Matsumoto et al (2001) report the 10 year survival rates of a randomized placebo-controlled trial in which colorectal cancer patients received cimetidine and oral 5-fluorouracil (5FU) or 5-FU alone as an adjuvant therapy following curative resection. In this small study a highly significant improvement in survival is demonstrated most notably in patients with node-positive (Dukes C) tumours (10 year survival – 85%). A further retrospective analysis suggests that this appeared to… CONTINUE READING