Cimetidine improves the therapeutic/toxic ratio of dapsone in patients on chronic dapsone therapy.

@article{Rhodes1995CimetidineIT,
  title={Cimetidine improves the therapeutic/toxic ratio of dapsone in patients on chronic dapsone therapy.},
  author={Lesley E Rhodes and Malcolm Drummond Tingle and Brian Kevin Park and P H Chu and Julian L Verbov and Peter Simon Friedmann},
  journal={The British journal of dermatology},
  year={1995},
  volume={132 2},
  pages={257-62}
}
We have previously shown that cimetidine, given concurrently for 2 weeks to patients on chronic dapsone therapy, reduced methaemoglobinaemia by inhibiting the formation of the toxic hydroxylamine metabolite of dapsone. The aim of the present study was to examine the effect of this combination on the benefit/toxic ratio of dapsone over a longer period. Eight patients (six dermatitis herpetiformis, one linear IgA disease, one folliculitis decalvans) on long-term dapsone 50-100 mg daily, took… CONTINUE READING

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