Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.

@article{AlMustafa1997CimetidineET,
  title={Cimetidine enhances the hepatoprotective action of N-acetylcysteine in mice treated with toxic doses of paracetamol.},
  author={Zaki H. Al-Mustafa and Amein Kadhem Al-Ali and Faud S. Qaw and Z Abdul-Cader},
  journal={Toxicology},
  year={1997},
  volume={121 3},
  pages={223-8}
}
Paracetamol, in toxic doses, is associated with extensive liver damage. This represents one of the common causes of morbidity and mortality in drug poisoning cases. This study was undertaken to investigate the possible potentiation of the hepatoprotective action of N-acetylcysteine (NAC) by cimetidine (CMD), an inhibitor of hepatic microsomal oxidative enzymes. The effects of NAC, cimetidine and the two in combination, administered 2 h post-paracetamol dose, on mortality, plasma glutamic… CONTINUE READING

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