Cimetidine assay in human plasma by liquid chromatography.

  title={Cimetidine assay in human plasma by liquid chromatography.},
  author={Niels Elgaard Larsen and Peter Hesselfeldt and Simon J. Rune and Eigill F. Hvidberg},
  journal={Journal of chromatography},
  volume={163 1},
An assay for the determination of cimetidine in human plasma is described. Cimetidine was extracted from alkalized plasma with ethyl acetate, washed once over hydrochloric acid, re-extracted into ethyl acetate, and the organic phase was evaporated to dryness. The residue was dissolved in ethanol and injected into a liquid chromatograph. In vitro sulphoxidation was found to occur in whole blood, for which reason the assay was performed in plasma. The accuracy of the method was found to be within… CONTINUE READING

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