Cilostazol Improves Developmental Competence of Pig Oocytes by Increasing Intraoocyte Cyclic Adenosine Monophosphate Level and Delaying Meiotic Resumption.

@article{Elahi2016CilostazolID,
  title={Cilostazol Improves Developmental Competence of Pig Oocytes by Increasing Intraoocyte Cyclic Adenosine Monophosphate Level and Delaying Meiotic Resumption.},
  author={F Nateghi Elahi and Hyun Joo Lee and Yung-jung Lee and Byung Won Park and Jonathan Yi Ho Lee and S-H Hyun and Elizabeth Lee},
  journal={Reproduction in domestic animals = Zuchthygiene},
  year={2016},
  volume={51 2},
  pages={
          220-6
        }
}
Cilostazol (CLZ) is a cyclic adenosine monophosphate (cAMP) modulator that influences the steady state of the meiotic stage. This study was conducted to determine the effects of CLZ treatment during in vitro maturation (IVM) on developmental competence of pig oocytes. Immature oocytes were exposed to 0 (control), 0.5, 2 and 4 μm CLZ during the first 22 h of IVM. Nuclear maturation, intraoocyte glutathione content and embryo cleavage after parthenogenesis (PA) and somatic cell nuclear transfer… CONTINUE READING
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