Ciliated air-liquid cultures as an aid to diagnostic testing of primary ciliary dyskinesia.

@article{Hirst2010CiliatedAC,
  title={Ciliated air-liquid cultures as an aid to diagnostic testing of primary ciliary dyskinesia.},
  author={Robert Anthony Hirst and Andrew R Rutman and Gwyneth I. Williams and Chris O'callaghan},
  journal={Chest},
  year={2010},
  volume={138 6},
  pages={
          1441-7
        }
}
BACKGROUND The diagnosis of primary ciliary dyskinesia (PCD) can prove difficult because of secondary damage of ciliated tissue. METHODS Here we audit culturing cells, obtained by nasal brushing, to a ciliated phenotype using an air-liquid interface method to determine if the effects of secondary damage on cilia were reduced following culture. RESULTS Of 231 patients consecutively referred for diagnostic testing, culture was attempted in 187, with 101 (54%) becoming ciliated. Of the 90… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 37 CITATIONS

Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline.

  • American journal of respiratory and critical care medicine
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Interleukin-13 stimulates production of nitric oxide in cultured human nasal epithelium

  • In Vitro Cellular & Developmental Biology - Animal
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

The answer is cilia, whatever the question may be!

  • Annals of translational medicine
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

Accuracy of Immunofluorescence in the Diagnosis of Primary Ciliary Dyskinesia.

  • American journal of respiratory and critical care medicine
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND