Ciliated Muconodular Papillary Tumors of the Lung: A Clinicopathologic Analysis of 10 Cases

@article{Kamata2015CiliatedMP,
  title={Ciliated Muconodular Papillary Tumors of the Lung: A Clinicopathologic Analysis of 10 Cases},
  author={Tsugumasa Kamata and Akihiko Yoshida and Tomoo Kosuge and Shun‐ichi Watanabe and Hisao Asamura and Koji Tsuta},
  journal={The American Journal of Surgical Pathology},
  year={2015},
  volume={39},
  pages={753–760}
}
Ciliated muconodular papillary tumors (CMPTs) are rare peripheral nodules of the lung first described in 2002. Because of their rarity and nonstandardized diagnostic terminology, CMPTs have been poorly recognized among pathologists. To better characterize these lesions, we undertook a detailed clinicopathologic and immunohistochemical study of 10 archival cases. Ten CMPTs occurred in 7 men and 3 women with a median age of 62 years. All were small peripheral nonendobronchial nodules with a mean… 
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Ciliated muconodular papillary tumor of the lung: A report of five cases
TLDR
The benign histological features and clinical courses in these five cases suggest that CMPT is an independent and benign tumor of the lung.
Ciliated Muconodular Papillary Tumors of the Lung Can Occur in Western Patients and Show Mutations in BRAF and AKT1
TLDR
This study is the first to describe that CMPT can occur in western (non-Asian) patients, and confirms BRAF V600E mutation as a probable driver in a subset of these tumors, along with AKT1 mutation, which further supports that C MPT are indolent pulmonary neoplasms.
Ciliated muconodular papillary tumor of the lung: report of five cases
TLDR
Five serial cases of ciliated muconodular papillary tumor of the lung are reported, with pathological findings included columnar ciliated cells with mucus lakes, consistent with the immunohistochemical staining.
Clinicopathological characteristic of ciliated muconodular papillary tumour of the lung
TLDR
The incidence of CMPT is low, and the prognosis is good, while intraoperative frozen sections cannot fully guide the surgical method, and sublobectomy may be enough without adjuvant treatment.
Ciliated muconodular papillary tumors of the lung: Cytologic features and diagnostic pitfalls in intraoperative examinations
TLDR
Although a CMPT is a rare lung tumor, it should be considered when cytological or histological examination of a solitary peripheral lung nodule shows non‐atypical ciliated cells and mucous cells surrounded by mucin.
Ciliated muconodular papillary tumor of the lung presenting with polymyalgia rheumatica-like symptoms: a case report.
TLDR
This case demonstrates two key points: the paraneoplastic symptoms of C MPT can indicate PMR, and it is difficult to diagnose peripheral lung tumors as CMPT unless there is a completely resected specimen available.
Ciliated Muconodular Papillary Tumors of the Lung: Distinct Molecular Features of an Insidious Tumor
TLDR
Distinct molecular and immune check point features of each component support the notion that ciliated columnar cells in CMPT are insidious with immune escape, indicating their malignant potential.
Ciliated Muconodular Papillary Tumors of the Lung.
TLDR
The clinical, radiographic, pathologic, and molecular findings of ciliated muconodular papillary tumors are reviewed, supporting that the lesion is indeed neoplastic.
Title Ciliated muconodular papillary tumors of the lung withKRAS / BRAF / AKT 1 mutation
TLDR
Histological and genetic profiles indicate that CMPT are likely neoplastic and exhibit features similar to mucinous adenocarcinoma, and suggests that some CMPTs may be a precursor lesion of mucinousAdenocARCinoma.
[A Case of Typical Ciliated Muconodular Papillary Tumor of the Lung: A Clinicopathological Analysis].
TLDR
CMPT can show many malignant tumor signs on imaging and is often mistaken for lung adenocarcinoma, but according to its typical histopathological characteristics and immunohistochemical phenotype, it can be differentiated from other pulmonary diseases.
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