Ciliary neurotrophic factor induces acute‐phase protein expression in hepatocytes

@article{Schooltink1992CiliaryNF,
  title={Ciliary neurotrophic factor induces acute‐phase protein expression in hepatocytes},
  author={Heidi Schooltink and Tanja Stoyan and Elke Roeb and Peter Claus Heinrich and Stefan Rose-John},
  journal={FEBS Letters},
  year={1992},
  volume={314}
}
IL‐1 receptor antagonist (IL‐1Ra) does not inhibit the production of C‐reactive protein or serum amyloid A protein by human primary hepatocytes. Differential regulation in normal and tumour cells
TLDR
It is concluded that IL‐1β and TNF‐α do not exert any significant effect on the synthesis of CRP and SAA by human primary hepatocytes.
Circulating levels of IL‐11 and leukaemia inhibitory factor (LIF) do not significantly participate in the production of acute‐phase proteins by the liver
TLDR
Results show that circulating levels of IL‐11 or LIF do not contribute significantly to the production of APP in vivo, and that they do not account for the difference in APP response between SLE and other inflammatory rheumatic diseases.
Regulation of tissue inhibitor of metalloproteinases‐1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures
TLDR
It is shown that the tissue inhibitor of metalloproteinases‐1 is expressed in rat hepatocytes in primary culture and regulated by inflammatory cytokines.
Ciliary Neurotrophic Factor May Activate Mature Astrocytes via Binding with the Leukemia Inhibitory Factor Receptor
TLDR
A mechanistic model is proposed in which, in the adult brain, a CNTF/LIFR interglial system may be modulated by neurons that synthesize CNTFRalpha, and it is proposed that this controversy may be solved by a shift in astroglial sensitivity to CNTF over time.
Acute phase proteins and transformed cells.
Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1.
TLDR
Results indicate that signaling through gp130 mediates potentiation of IL-1 activities, and that gp130-dependent cytokines may be important feedback regulators of inflammation through the activation of the hypothalamus-pituitary-adrenal axis and the potentiated of acute-phase protein synthesis.
Cytokine-Induced Nuclear Factor Kappa B Activation Promotes the Survival of Developing Neurons
TLDR
It is demonstrated that NF-κB plays a key role in mediating the survival response of developing neurons to cytokines, including in cytokine-dependent developing sensory neurons.
Ciliary neurotrophic factor: Pharmacokinetics and acute‐phase response in rat
TLDR
The pharmacokinetics of radioiodinated CNTF after intravenous injection into rats are determined and the short half‐life and the inflammatory side effect may limit the clinical usefulness of systematically administered CNTF in the treatment of human motoneuron disorders.
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.
TLDR
To examine whether IL1Ra is produced by liver cells with characteristics resembling an acute-phase protein, human primary hepatocytes isolated from liver biopsies and HepG2 hepatoma cells were stimulated with IL-1beta, IL-6, and TNFalpha and sIL-1Ra was present in the supernatants of both cells.
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The coordinate increase in the hepatic production of the acute phase plasma proteins appears to be mediated by several cytokines produced by different cell types, providing additional evidence for the close relationship between acute phase regulation of the liver and control of proliferation and differentiation of hemopoietic cells by identical cytokines.
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