Ciliary neurotrophic factor induces acute‐phase protein expression in hepatocytes

  title={Ciliary neurotrophic factor induces acute‐phase protein expression in hepatocytes},
  author={Heidi Schooltink and Tanja Stoyan and Elke Roeb and Peter Claus Heinrich and Stefan Rose-John},
  journal={FEBS Letters},
IL‐1 receptor antagonist (IL‐1Ra) does not inhibit the production of C‐reactive protein or serum amyloid A protein by human primary hepatocytes. Differential regulation in normal and tumour cells
It is concluded that IL‐1β and TNF‐α do not exert any significant effect on the synthesis of CRP and SAA by human primary hepatocytes.
Circulating levels of IL‐11 and leukaemia inhibitory factor (LIF) do not significantly participate in the production of acute‐phase proteins by the liver
Results show that circulating levels of IL‐11 or LIF do not contribute significantly to the production of APP in vivo, and that they do not account for the difference in APP response between SLE and other inflammatory rheumatic diseases.
Regulation of tissue inhibitor of metalloproteinases‐1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures
It is shown that the tissue inhibitor of metalloproteinases‐1 is expressed in rat hepatocytes in primary culture and regulated by inflammatory cytokines.
Ciliary Neurotrophic Factor May Activate Mature Astrocytes via Binding with the Leukemia Inhibitory Factor Receptor
A mechanistic model is proposed in which, in the adult brain, a CNTF/LIFR interglial system may be modulated by neurons that synthesize CNTFRalpha, and it is proposed that this controversy may be solved by a shift in astroglial sensitivity to CNTF over time.
Acute phase proteins and transformed cells.
Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1.
Results indicate that signaling through gp130 mediates potentiation of IL-1 activities, and that gp130-dependent cytokines may be important feedback regulators of inflammation through the activation of the hypothalamus-pituitary-adrenal axis and the potentiated of acute-phase protein synthesis.
Cytokine-Induced Nuclear Factor Kappa B Activation Promotes the Survival of Developing Neurons
It is demonstrated that NF-κB plays a key role in mediating the survival response of developing neurons to cytokines, including in cytokine-dependent developing sensory neurons.
Ciliary neurotrophic factor: Pharmacokinetics and acute‐phase response in rat
The pharmacokinetics of radioiodinated CNTF after intravenous injection into rats are determined and the short half‐life and the inflammatory side effect may limit the clinical usefulness of systematically administered CNTF in the treatment of human motoneuron disorders.
Interleukin 1 receptor antagonist (IL-1Ra) is an acute-phase protein.
To examine whether IL1Ra is produced by liver cells with characteristics resembling an acute-phase protein, human primary hepatocytes isolated from liver biopsies and HepG2 hepatoma cells were stimulated with IL-1beta, IL-6, and TNFalpha and sIL-1Ra was present in the supernatants of both cells.


Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor.
The coordinate increase in the hepatic production of the acute phase plasma proteins appears to be mediated by several cytokines produced by different cell types, providing additional evidence for the close relationship between acute phase regulation of the liver and control of proliferation and differentiation of hemopoietic cells by identical cytokines.
IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo.
The notion that direct interaction of IL-6 with the liver is an essential part in initiating the hepatic acute phase reaction is supported.
Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro.
Results suggest that OM plays a role as a mediator of APP synthesis in inflammatory responses and was shown to act additively with IL-6 or leukemia inhibitory factor and synergistically with glucocorticoid or IL-1 in the induction of specific APP.
Induction of rat acute‐phase proteins by interleukin 6 in vivo
Hepatic mRNA levels of β‐fibrinogen, α2‐macroglobulin, cysteine proteinase inhibitor, α1‐acid glycoprotein and albumin were measured at different times after the administration of rhIL 6.
Biology of interleukin 1
  • C. Dinarello
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1988
IL 1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites and acts synergistically with other cytokines, particularly tumor necrosis factor.