Ciliary function and Wnt signal modulation.

  title={Ciliary function and Wnt signal modulation.},
  author={Jantje M. Gerdes and Nicholas Katsanis},
  journal={Current topics in developmental biology},
With the increase in complexity of morphogenetic signaling cascades over the course of evolution and the emergence of broadly ciliated organisms, the cilium seems to have acquired a role as regulator of paracrine signal transduction. Recently, several lines of evidence have provided a link between basal body and ciliary proteins and Wnt signaling. In this chapter, we will evaluate the evidence linking the basal body and cilium with the regulation of beta-catenin-dependent (canonical) and beta… CONTINUE READING

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