Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and Ran-GTP

  title={Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and Ran-GTP},
  author={John F. Dishinger and Hooi Lynn Kee and Paul M. Jenkins and Shuling Fan and Toby Hurd and Jennetta W. Hammond and Yen Nhu-Thi Truong and Ben L Margolis and Jeffrey R. Martens and Kristen J Verhey},
  booktitle={Nature Cell Biology},
The biogenesis, maintenance and function of primary cilia are controlled through intraflagellar transport (IFT) driven by two kinesin-2 family members, the heterotrimeric KIF3A/KIF3B/KAP complex and the homodimeric KIF17 motor. How these motors and their cargoes gain access to the ciliary compartment is poorly understood. Here, we identify a ciliary localization signal (CLS) in the KIF17 tail domain that is necessary and sufficient for ciliary targeting. Similarities between the CLS and classic… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 117 extracted citations


Publications referenced by this paper.
Showing 1-10 of 39 references

Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid

  • K Tahara
  • J Cell Biol
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…