Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and Ran-GTP

@inproceedings{Dishinger2010CiliaryEO,
  title={Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-β2 and Ran-GTP},
  author={John F. Dishinger and Hooi Lynn Kee and Paul M. Jenkins and Shuling Fan and Toby Hurd and Jennetta W. Hammond and Yen Nhu-Thi Truong and Ben L Margolis and Jeffrey R. Martens and Kristen J Verhey},
  booktitle={Nature Cell Biology},
  year={2010}
}
The biogenesis, maintenance and function of primary cilia are controlled through intraflagellar transport (IFT) driven by two kinesin-2 family members, the heterotrimeric KIF3A/KIF3B/KAP complex and the homodimeric KIF17 motor. How these motors and their cargoes gain access to the ciliary compartment is poorly understood. Here, we identify a ciliary localization signal (CLS) in the KIF17 tail domain that is necessary and sufficient for ciliary targeting. Similarities between the CLS and classic… CONTINUE READING
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Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid

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