Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.

@article{Xiao2006CilialikeSA,
  title={Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.},
  author={Zhousheng Xiao and Shiqin Zhang and Josh Mahlios and Gan Zhou and Brenda S. Magenheimer and Dayong Guo and Sarah L Dallas and Robin L. Maser and James P. Calvet and Lynda Bonewald and Leigh Quarles},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 41},
  pages={30884-95}
}
We examined the osteoblast/osteocyte expression and function of polycystin-1 (PC1), a transmembrane protein that is a component of the polycystin-2 (PC2)-ciliary mechano-sensor complex in renal epithelial cells. We found that MC3T3-E1 osteoblasts and MLO-Y4 osteocytes express transcripts for PC1, PC2, and the ciliary proteins Tg737 and Kif3a. Immunohistochemical analysis detected cilia-like structures in MC3T3-E1 osteoblastic and MLO-Y4 osteocyte-like cell lines as well as primary osteocytes… CONTINUE READING

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