Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.

@article{Yoshiba2012CiliaAT,
  title={Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2.},
  author={Satoko Yoshiba and Hidetaka Shiratori and Ivana Y-T Kuo and Aiko Kawasumi and Kyosuke Shinohara and Shigenori Nonaka and Yasuko Asai and Genta Sasaki and Jos{\'e} Ant{\'o}nio Belo and Hiroshi M Sasaki and Junichi Nakai and Bernd Dworniczak and Barbara E Ehrlich and Petra Pennekamp and Hiroshi Hamada},
  journal={Science},
  year={2012},
  volume={338 6104},
  pages={
          226-31
        }
}
Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We report that the Ca(2+) channel Polycystin-2 (Pkd2) is required specifically in the perinodal crown cells for sensing the nodal flow. Examination of mutant forms of Pkd2 shows that the ciliary localization of Pkd2 is essential for correct L-R patterning. Whereas Kif3a mutant embryos, which lack all cilia, failed to… CONTINUE READING
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